30 research outputs found
Comparison of Bandwidth of MALN with Four Tree (Ft) Network
In this paper Modified Alpha Network has been compared with the existing Four Tree Network on the basis of different Performance Parameters
Architecture Analysis of NIASN
The Multi Stage Interconnection Network(MIN) is called as Fault-Tolerant if it is able to work, even in the presence of critical faults. Routing method and algorithm plays a vital role to rote the data from source to destination. In this paper the architecture of a proposed Interconnection Network named as New Irregular Augmented Shuffle Exchange Network (NIASN) has been evaluated
Evaluation of Routes from Sources to Destinations in Fault- Free and Fault Scenarios
In this paper, the design and analysis of the proposed Fault-Tolerant Irregular Dynamic Modified Alpha Network has been presented. This network has been designed by reducing one stage of SEs in the existing Alpha Network. This makes the proposed network cost effective
Evaluation of Path Lengths in Proposed Triangle Network
Routing tag provides the algorithm to pass the data from source to destination in a network. In this paper Fault Tolerance of the proposed MIN Triangle has been analysed . All the path lengths available from source to destination have been found
Comparision of Routes Availability of MALN with Four Tree MIN
In this paper, paths available in proposed MIN MALN and existing MIN Four Tree (FT) Network have been evaluatedand compared Permutation Passables which depend on the probability of request generation at the input has been studied
Survey of Vertical Handoff Decision Criteria in LTE Cellular Networks
Vertical handover advantage brilliant importance because of the upgrades in mobility fashions by way of the Fourth era (4G) technology. A handover desire scheme in LTE networks both based totally on unmarried or multiple criteria. The wide variety of standards is right away depending on the overall handover time. In addition, the time required for deciding on a target network at some point of handover is also extended with the growth in a number of parameters. Conventional handover choice Strategies are specifically based at the unmarried parameter. But, with the advent of heterogeneous Wi-Fi networks, the overall performance of those unmarried parameter choice schemes is highly decreased. Consequently, researchers introduce multirequirements handover selection schemes. those enhancements are restricted to specific situations and for this reason do now not offer help for mounted mobility. Further, numerous schemes are proposed
Vertical Handoff Decision Criteria with LTE Network
A handover decision scheme in LTE networks either based on single or multiple criteria. The number of criteria is directly depending on the totalhandovertime.A vertical handover decision algorithm based on the fuzzy control theory. The algorithm takes into consider the factors of Power Level, Cost and Bandwidth. After establishing the membership functions, membership degrees of corresponding factors can be determined, which are processed by the Weight Vector. Finally, the Fuzzy Vertical Handoff Decision Vector is derived and vertical handover decision can be made. It is shown through simulation that the algorithm realizes the optimized vertical handover by evaluating and analyzing various input parameters
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570